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As of March 24, 2020, a combination of Azithromycin taken together
with Hydroxychloroquine
has been shown to stop COVID19 within hours, but only in a
very small cohort of seriously ill patients. This combo is NOT
FDA approved. No medication is widely available, so the
following information is offered as a template. It is based on
the currently known Pathophysiology of the COVID19 RNA Virus.
Although drugs like Merck's cd20 limiting Rituximab
might be applicable to some pathology where overexpression of
antibodies is involved, cost and supply may be prohibitive.
The present goal is to research the numerous reactions and
characteristics of COVID19, and pair them to readily available
supplements that have peer reviewed and published
abstracts (research) that show positive clinical outcomes,
which point to the possible suppression of severe symptoms
associated with this Pandemic. This is NOT a "cure," and
is meant only to attempt to provide medical INFORMATION to
help MITIGATE COVID19 Adverse Reactions. These include, but
are not limited to: PYROPTOSIS, "Cytokine Storm," and SEPSIS,
to potentially render them less life threatening.
Note
to Clinicians: If Saturated O2 Levels remain low,
please consider Rouleau
and Agglutination in your
dx.
THIS IS NOT THE FINAL DRAFT. This is a
work in progress that will be updated as time permits, and
verifiable facts become available. It may be removed without
warning when someone else with the resources and knowledge
decides to take over this task. Please do not copy without
permission, because this information is frequently updated,
and you may be libel for out-of-date information that may
harm.
Copyright© 2020, Lloyd W. Phillips, All
Rights Reserved
Sound Recording Copyright℗ 2020, Lloyd W. Phillips, All Rights
Reserved Over All Media
=================================
At the time of this writing, the COVID19 RNA virus is reported
to produce abnormal levels of NLRP3 inflammasomes, IL1β,
TNF-ά, NF-kB, and possibly deadly quantities of inflammatory
IL6 - up to or exceeding 8000pg/ (normal is ~94pg/). The
information provided here focuses on the reactions that can
take place if the body fails to regulate or limit immune
response reactions from this group. It appears that the virus
may be responsible for a good portion of the cell damage
before the immune system "kicks in" apoptosis due to NK Cells
or possible NON IgE mediated cell response?? Ironically,
as virus levels attenuate, Interleukin 6 has been reported to
dramatically and dangerously increase, resulting in a storm of
cytokines measured at 8000pg/ (Cytokine Storm).
Incubation reportedly ranges from days to a couple weeks,
according to the CDC, but various other sources report that it
may start as sniffles, you may then feel well, then, around
the 5th day, it can SUDDENLY hit you like a "ton of bricks"
all at once. One Hollywood Florida man reports that he became
progressively sicker, then on the 9th day was admitted to
hospital, thought he would die, then requested the
experimental Azithromycin & Hydrochloroquine iv cocktail.
His doctor agreed. He went from fever and labored breathing
the night before, to waking up around 4 am, with no fever, and
able to breath comfortably.
Known symptoms MAY or MAY NOT include, and are not limited to:
- Sniffles
- Sore
Throat
- Headache (possibly Infected /
Inflamed Meninges)
- Diarrhea
- Stomach Cramps
- Fever (Tylenol or Acetaminophen
is suggested)
- Body Aches
- Cough
- Loss
of Smell (Hyposmia)
- * Saturated oxygen level below
90, Contact Doctor
- * Mild Chest Pain (hurts while
breathing in): Contact Doctor Immediately
- * Sudden New Symptoms of
Disorientation: Contact Doctor Immediately / Notify ER
- ** Loss of Consciousness:
Transport
- ** Acute (severe) Trouble
Breathing; Blue Face or Lips: Transport
- ** Acute (severe) Chest Pain:
Transport
- Pyroptosis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087413/
- Sepsis
- Sudden Reactivation of Latent
(Dormant) Pathogens, including, but not limited to: EBV,
CMV, Spirochetes, Protozoa, etc.
- Supraventricular Tachycardia
/ Arrhythmias:
- Caution: Do not mistake
Takotsubo Cardiomyopathy (temporary) for Arrhythmogenic
Right Ventricle Dysplasia, ARVD, which is typically
inherited in about 1 in 5000 people, with reportedly heavy
clusters in Italy.
- Sudden Acquired Histamine
Intolerance (Low Histamine Diet & avoid Lectins)
- Orthostatic Intolerance,
including Postural Orthostatic Intolerance (POTS).
CAUTION: Do NOT take hot showers if signs of POTS or
lightheadedness are present.
The following list of commonly available supplements,
according to peer-reviewed and published research, is given
for your consideration:
Inflammasome -
Wikipedia definition:
Inflammasomes are cytosolic multiprotein oligomers of the
innate immune system responsible for the activation of
inflammatory responses. Activation and assembly of the
inflammasome promotes proteolytic cleavage, maturation and
secretion of pro-inflammatory cytokines interleukin 1β and
interleukin 18, as well as cleavage of Gasdermin-D. The
N-terminal fragment resulting from this cleavage induces a
pro-inflammatory form of programmed cell death distinct from
apoptosis, referred to as pyroptosis.
However, we will only reference Peer Reviewed & Published
works:
https://www.sciencedirect.com/topics/neuroscience/inflammasome
=======================================
Readily Available Supplements for NLRP3 Suppression:
=======================================
Possible aid to inhibit transmission, according to available
peer reviewed and published data:
Peer Reviewed & Published Abstract on Olive Leaf: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566934/
Olive Leaf is available in a Nasal Spray (Seagate Brand), and
may help to slow or inhibit viral and bacterial infection
according to Published data at NIH.
========================
The Unexpected CRITICAL Importance of
SELENIUM in COVID19 Replication and Pyroptosis
After
much research, I discovered that many of the life-threatening
immune responses in the current Pandemic were controlled by
Selenium (Se) compounds, and the most severe symptoms were
surprisingly consistent with a Selenium Deficiency. But could
Americans really be Selenium Deficient? I sadly learned that
this could be true, including myself .... even though I take
vitamins, minerals, and eat balanced meals. I found my
expensive multi-vitamins did NOT contain any selenium. My
Multi-Mineral only had a small amount. But what worried me the
most is that the Roundup residue I was eating in my Oatmeal,
bread, pasta, and other foods with Glyphosate residue from
RoundUp, had the ability to chelate (degrade) the precious
little trace minerals such as selenium, copper, etc., in my
diet. Copper is absolutely necessary for the Tight-Gap
Junctions holding arteries and blood vessels together. I
remember reading that the first batch of Turkey Chow made by a
certain company back in the 1950's, failed to contain copper.
A considerable amount of Turkeys died BEFORE Thanksgiving
because of Aneurysms, due to lack of copper in the first
batches of Turkey Chow. Low copper is also associated with
Leukemia via Semaphorin 7, possibly due to low H3K4
TriMethylation, which requires trace amounts of copper. Copper
is also necessary for Stem Cell Production via cell
differentiation in bone marrow, especially if you quickly need
replacement heart muscle cells after a heart attack. (I'm
wondering right now, if the body replaces Right Ventricle
muscle with fat, as found in Arrhythmogenic Right Ventricular
Dysplasia, if copper becomes depleted???)
So let's do a quick recap: Americans and Italians might very
well be selenium deficient because of the foods we eat. (in
addition to the over 320,000 Chinese citizens reportedly
living in Italy)! Glyphosate residue from Monsanto's RoundUp®
Suppresses the ability for plants, such as wheat, corn,
soybeans, etc., and the people and animals that eat this
stuff, to properly uptake the mineral Selenium (Se). My family
eats these foods. But these RoundUp compromised, selenium
deficient plants are also used to feed to livestock and other
animals in the Human Food Chain, so the meats we eat are
probably also deficient in trace minerals and selenium. To
make matters even worse, Selenium is rapidly used, and can
become critically low during a viral infection, as reported in
the Abstract excerpt below, because selenium and other
micronutrients are in greater demand during a viral infection.
A selenium deficiency can lead
to a viral replication loop, in which COVID19 virii may
actually replicate (multiply) faster, and do
more damage due to ROS (Reserve Oxygen Species) production.
Here is an excerpt from that Peer Reviewed Abstract that was just
published in September of 2019:
"Reactive
oxygen species (ROS) are frequently produced during viral
infections. Generation of these ROS can be both beneficial and
detrimental for many cellular functions. When overwhelming the
antioxidant defense system, the excess of ROS induces
oxidative stress. Viral infections lead to diseases
characterized by a broad spectrum of clinical symptoms, with
oxidative stress being one of their hallmarks. In
many cases, ROS can, in turn, enhance viral
replication leading to an amplification loop.
Another important parameter for viral replication and
pathogenicity is the nutritional status of the host.
Viral infection simultaneously increases the demand for
micronutrients and causes their loss, which leads to a
deficiency that can be compensated by micronutrient
supplementation. Among the nutrients implicated in viral
infection, selenium (Se) has an important role in
antioxidant defense, redox signaling and redox homeostasis.
Most of biological activities of selenium is performed through
its incorporation as a rare amino acid selenocysteine in the
essential family of selenoproteins. Selenium deficiency, which
is the main regulator of selenoprotein expression, has been
associated with the pathogenicity of several viruses. In
addition, several selenoprotein members, including glutathione
peroxidases (GPX), thioredoxin reductases (TXNRD) seemed
important in different models of viral replication."
I
included this 2015 Abstract because it has a wealth of
information relating to Viral Infection and "Cytokine Storm"
scenario. It details SELENIUM's important role in CD4 cell
differentiation, and how host cells are protected (from
Pyroptosis). It provides a rather thorough review of
Selenium's role in Infectious Disease:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288282/
In
researching data for this work, I noted a severe selenium
deficiency listed for Chinese soil. Perhaps that may be a
contributing factor for the fast spread and severity of the
recent Pandemic in China.
I
also researched Selenium in soil worldwide, including this
PNAS Abstract that shows current and projected soil
concentrations of Selenium Worldwide. Here is an Excerpt
overview:
"The trace element selenium is
essential for human health and is required in a narrow dietary
concentration range. Insufficient selenium intake has
been estimated to affect up to 1 billion people worldwide.
Dietary selenium availability is controlled by soil–plant
interactions, but the mechanisms governing its broad-scale soil
distributions are largely unknown. Using data-mining techniques,
we modeled recent (1980–1999) distributions and identified
climate–soil interactions as main controlling factors.
Furthermore, using moderate climate change projections, we
predicted future (2080–2099) soil selenium losses from 58% of
modeled areas (mean loss = 8.4%). Predicted losses from
croplands were even higher, with 66% of croplands predicted to
lose 8.7% selenium. These losses could increase the worldwide
prevalence of selenium deficiency."
https://www.pnas.org/content/114/11/2848
SUMMATION: Selenium is CRITICAL to protect Humans from
viruses, especially powerful and fst spreading viruses like
COVID19, with an infection rate estimated to be 1000x stronger
than average.
=======================
SMOKING
GUN: GLYPHOSATE IN ROUNDUP SUPPRESSES THE CRITICAL NUTRIENT
"SELENIUM," NOT ONLY BY SUPPRESSING UPTAKE IN PLANTS, BUT
ALSO THE POULTRY, CATTLE, AND OTHER SOURCES OF NUTRIENTS IN
THE HUMAN FOOD CHAIN THAT EAT ROUNDUP RESIDUE IN THEIR FEED.
RoundUp ALSO SUPPRESSES THE HUMAN CYP450 PATHWAY THAT
SUPPLIES ENZYMES, HORMONES, ETC., NECESSARY FOR HUMAN LIFE.
I
foresee problems in Monsanto's future, and trouble for the
Federal Government, the Surgeon General, HHS, the FDA and CDC,
politicians, lobbyists, and others who profited and allowed
Americans to Die because Industry and the Suppression of
product labeling was more important than Human Life.
I not only found that dietary Selenium
was generally low worldwide, I needed to understand WHY it
appears to be low in First World Countries like Italy and the
United States of America. While soil levels of Selenium are
being depleted, there had to be at least one additional
factor. There was. Its name is MONSANTO. Monsanto manufactures
RoundUP. RoundUP contains GLYPHOSATE. Glyphosate inhibits the
uptake of Selenium AND OTHER MICRONUTRIENTS, such as Iron
and..... When I saw "copper," I knew I hit the
Jackpot. Copper is necessary for H3K4 Tri-Methylation, a
source of micronutrients for the Semaphorins that provide
instructions and control "Cone Guidance and Proliferation" for
Axons. Nw we know they do a lot more, such as checking to make
sure DNA is an exact copy of the original - we even associate
the failure of Sema7 with Leukemia. But copper does a lot
more: It's involved in cell differentiation relating to bone
marrow; it is necessary for the production of stem cells, ie:
the replacement of dead cells in the heart after a heart
attack, plus a lot more. This RoundUp crap is killing us in so
many different ways. I found this Abstract relating to Celiac,
but the author was so thorough that her 2013 detailed research
about CYP450 and how GLYPHOSATE CHELATES MINERALS can be
applied here:
"Glyphosate
is known to inhibit cytochrome P450 enzymes. Deficiencies in
iron, cobalt, molybdenum, copper and other rare metals
associated with celiac disease can be attributed to glyphosate's
strong ability to chelate these elements. Deficiencies in
tryptophan, tyrosine, methionine and selenomethionine associated
with celiac disease match glyphosate's known depletion of these
amino acids. Celiac disease patients have an increased risk to
non-Hodgkin's lymphoma, which has also been implicated in
glyphosate exposure. Reproductive issues associated with celiac
disease, such as infertility, miscarriages, and birth defects,
can also be explained by glyphosate. Glyphosate residues in
wheat and other crops are likely increasing recently due to the
growing practice of crop desiccation just prior to the harvest.
We argue that the practice of “ripening” sugar cane with
glyphosate may explain the recent surge in kidney failure among
agricultural workers in Central America."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945755/
===== Below is additional info on what can be used to help
formulate a "SUPPRESSION PROTOCOL" ======
Curcumin Represses NLRP3 Inflammasome Activation via
TLR4/MyD88/NF-κB and P2X7R Signaling in PMA-Induced
Macrophages: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056188/
INFO: Curcumin for Muscle Growth | T Nation
www.t-nation.com/supplements/curcumin-for-muscle...
The LD50 (lethal dose) has been found to be >2000mg/kg in
mice, which if accurate and extrapolated to humans puts the
LD50 for a 175-pound male at around 160,000 mg.
========================
Quercetin suppresses NLRP3 inflammasome activation in
epithelial cells triggered by Escherichia coli O157:H7.: https://www.ncbi.nlm.nih.gov/pubmed/28476502
HIST-RESIST (pureFormulas.com) contains 200mg per capsule:
https://www.pureformulas.com/hist-resist-120-vegetable-capsules-by-vinco.html
========================
Mangosteen (a-Mangostin): α-Mangostin suppresses NLRP3
inflammasome activation via promoting autophagy in
LPS-stimulated murine macrophages and protects against
CLP-induced sepsis in mice.: https://www.ncbi.nlm.nih.gov/pubmed/30927050
========================
Quercetin and Ascorbic Acid (Vitamin C) Suppress
Fructose-Induced NLRP3 Inflammasome Activation by Blocking
Intracellular Shuttling of TXNIP in Human Macrophage Cell
Lines.: https://www.ncbi.nlm.nih.gov/pubmed/28326454
========================
I also take what would currently be considered "large
quantities" of Iodoral, an iodine substance, and have done so
for approximately 20 years. Prior to antibiotics, iodine was
used to treat various infections and diseases.
========================
NAC has A good safety record and
proven efficacy with certain viruses, but currently appears
to be unproven with COVID19 as of this writing:
"The antioxidant N-acetyl-L-cysteine
(NAC) had been shown to inhibit replication of seasonal
human influenza A viruses. Here, the effects of NAC on virus
replication, virus-induced pro-inflammatory responses and
virus-induced apoptosis were investigated in H5N1-infected
lung epithelial (A549) cells. NAC at concentrations ranging
from 5 to 15 mM reduced H5N1-induced cytopathogenic effects
(CPEs), virus-induced apoptosis and infectious viral yields
24 h post-infection. NAC also decreased the production of
pro-inflammatory molecules (CXCL8, CXCL10, CCL5 and
interleukin-6 (IL-6)) in H5N1-infected A549 cells and
reduced monocyte migration towards supernatants of
H5N1-infected A549 cells. The antiviral and
anti-inflammatory mechanisms of NAC included inhibition of
activation of oxidant sensitive pathways including
transcription factor NF-kappaB and mitogen activated protein
kinase p38."
HOWEVER,
research shows that NAC may be less effective with some
viral STRAINS:
N-acetylcysteine (NAC) has been
recently proposed as an adjuvant therapeutic drug for
influenza pneumonia in humans. This proposal is based on
its ability to restrict influenza virus replication in
vitro and to attenuate the severity of the disease
in mouse models. Although available studies were made with
different viruses (human and avian), published information
related to the anti-influenza spectrum of NAC is scarce.
In this study, we show that NAC is unable to alter the
course of a fatal influenza pneumonia caused by
inoculation of a murinized swine H1N1 influenza virus. NAC
was indeed able to inhibit the swine virus in vitro but
far less than reported for other strains. Therefore,
susceptibility of influenza viruses to NAC appears to be
strain-dependent, suggesting that it cannot be considered
as a universal treatment for influenza pneumonia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104374/
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